Accutane (isotretinoin) can be recommended for patients with nodular acne that did not benefit enough from taking other meds, including antibiotics that can be sometimes prescribed in such cases. Do not donate your blood during the treatment or during a month after it is over, as there is a risk the blood may be given to a female that may be pregnant at that moment. Make sure your health care provider is aware of any medical conditions you have that may require a dose adjustment or monitoring of your condition- such as depression, anorexia nervosa, high triglyceride levels, history of suicide attempt, diabetes, asthma, heart or liver disease, mental illness, osteoporosis, and some other ones that can be important. Accutane needs to be taken regularly for your acne to be treated properly. Make sure you follow the recommendations of your doctor. Do not start taking any new medications, as interactions are possible. The following drugs have been reported to interact with Accutane: vitamin A supplements, minocycline, medications for seizures, doxycycline, phenytoin, demeclocycline, prednisone, tetracycline, dexamethasone, and methylprednisolone.